TY - RPRT AU - Pullum, Thomas W. CY - Rockville, Maryland, USA TI - Analysis of sickle cell genotypes of young children in Nigeria using the 2018 DHS Survey T2 - DHS Working Papers No. 175 PB - ICF PY - 2020 UR - https://www.dhsprogram.com/pubs/pdf/WP175/WP175.pdf AB - A DHS survey conducted in Nigeria in 2018 included sickle cell genotyping of a subsample of children age 6-59 months. The survey was the first population-based household survey to include sickle cell genotyping of children at a national level. This working paper provides continued analysis of the data that was not possible in the main survey report. The paper examines the spatial distribution of the problematic genotypes and alleles and their relationship with indicators of child health, and compares with evidence from clinical studies of higher mortality for the SS and SC genotypes, and lower mortality for the AS genotype, which has a known protective effect against malaria. We find serious limitations in the capacity of these data to quantify differences in the mortality risk from sickle cell disease, malaria, or any other cause. However, we found that the siblings of genotyped children with sickle cell disease are about 2.5 times as likely to have died as the siblings of other genotyped children. The only significant relationship with childhood illness is with severe anemia. The main value of the data is the description of the spatial distribution of the genotypes and alleles within Nigeria. The S and C genes are primarily concentrated in most states in the South West Zone, including Lagos. Spatial information such as this will be informative for education and intervention campaigns. N1 - For assistance using downloaded citations from The DHS Program, please visit http://dhsprogram.com/publications/Citing-DHS-Publications.cfm. This study was conducted with support from the United States Agency for International Development (USAID) through The DHS Program (#720-OAA-18C-00083). The views expressed are those of the authors and do not necessarily reflect the views of USAID or the United States Government. ER -