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On the discriminatory and predictive accuracy of the RDT against the microscopy in the diagnosis of malaria among under-five children in Nigeria
Authors: Adeniyi Francis Fagbamigbe
Source: Malaria Journal, 18:46; DOI: 10.1186/s12936-019-2678-1
Topic(s): Child health
Children under five
Malaria
Country: Africa
  Nigeria
Published: FEB 2019
Abstract: Background Accurate identification of malaria cases is crucial to the management of cases and the eventual success of malaria eradication agenda. This study is designed to evaluate the discriminatory and predictive accuracy of malaria rapid diagnostic tests (RDTs) in Nigeria. Methods The data obtained during the 2015 Nigeria Malaria Indicator Survey was used to quantify the discriminatory accuracy of the RDT against the microscopy through the analysis of its sensitivity, specificity, positive (LR+) and negative (LR-) likelihood ratio. The positive (PPV) and negative (NPV) predictive values, area under the receiver operating characteristic curve, and diagnostic odds ratio were used to assess the predictive accuracy of the RDTs using expert microscopy as a gold standard at p?=?0.05. The McNemar paired test and the Kappa statistics were used to assess the level of agreement between the diagnostic tests. Results There was a significant but not an excellent agreement between the results of the RDT and microscopy tests (p?
Web: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-019-2678-1